Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study.
Identifieur interne : 001021 ( Main/Exploration ); précédent : 001020; suivant : 001022Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study.
Auteurs : M. Kobayashi [Japon] ; H. Nakamura ; J. Yodoi ; K. ShiotaSource :
- Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia [ 1122-6714 ] ; 2001.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antioxydants (MeSH), Développement embryonnaire et foetal (MeSH), Embryon de mammifère (enzymologie), Femelle (MeSH), Glutarédoxines (MeSH), Grossesse (MeSH), Immunohistochimie (MeSH), Myocarde (enzymologie), Mâle (MeSH), Oxidoreductases (MeSH), Protéines (analyse), Protéines (métabolisme), Souris (MeSH), Souris de lignée ICR (MeSH), Spécificité d'organe (MeSH), Système nerveux (embryologie), Système nerveux (enzymologie), Thiorédoxines (analyse), Thiorédoxines (métabolisme), Âge gestationnel (MeSH), Épithélium (enzymologie).
- MESH :
- analyse : Protéines, Thiorédoxines.
- embryologie : Système nerveux.
- enzymologie : Embryon de mammifère, Myocarde, Système nerveux, Épithélium.
- métabolisme : Protéines, Thiorédoxines.
- Animaux, Antioxydants, Développement embryonnaire et foetal, Femelle, Glutarédoxines, Grossesse, Immunohistochimie, Mâle, Oxidoreductases, Souris, Souris de lignée ICR, Spécificité d'organe, Âge gestationnel.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (MeSH), Embryo, Mammalian (enzymology), Embryonic and Fetal Development (MeSH), Epithelium (enzymology), Female (MeSH), Gestational Age (MeSH), Glutaredoxins (MeSH), Immunohistochemistry (MeSH), Male (MeSH), Mice (MeSH), Mice, Inbred ICR (MeSH), Myocardium (enzymology), Nervous System (embryology), Nervous System (enzymology), Organ Specificity (MeSH), Oxidoreductases (MeSH), Pregnancy (MeSH), Proteins (analysis), Proteins (metabolism), Thioredoxins (analysis), Thioredoxins (metabolism).
- MESH :
- chemical , analysis : Proteins, Thioredoxins.
- chemical , metabolism : Proteins, Thioredoxins.
- chemical : Antioxidants, Glutaredoxins, Oxidoreductases.
- embryology : Nervous System.
- enzymology : Embryo, Mammalian, Epithelium, Myocardium, Nervous System.
- Animals, Embryonic and Fetal Development, Female, Gestational Age, Immunohistochemistry, Male, Mice, Mice, Inbred ICR, Organ Specificity, Pregnancy.
Abstract
The ontogenesis of two anti-oxidative enzymes, thioredoxin (TRX) and glutaredoxin (GRX), was examined immunohistochemically in mouse embryos and fetuses at various developmental stages. They were found to be localized in various tissues, with some tissue specificity and temporal sequence. Both TRX and GRX began to be expressed in many tissues at embryonic (E) day E10 or E11 and tended to increase as the developmental stage advanced. In the heart and neuroepithelium, however, their immunoreactivity was already positive at E8.5. In some fetal organs like the liver, pancreas and kidney, TRX and GRX showed heterogeneous localization, suggesting that their expression may reflect the variable functional states of the cell. These results suggest that TRX and GRX may be associated with tissue differentiation in embryos and fetuses are involved in the acquisition of the capacity of resistance against oxygen radicals.
PubMed: 11732570
Affiliations:
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Le document en format XML
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Shiota</name></author></analytic><series><title level="j">Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia</title><idno type="ISSN">1122-6714</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antioxidants (MeSH)</term><term>Embryo, Mammalian (enzymology)</term><term>Embryonic and Fetal Development (MeSH)</term><term>Epithelium (enzymology)</term><term>Female (MeSH)</term><term>Gestational Age (MeSH)</term><term>Glutaredoxins (MeSH)</term><term>Immunohistochemistry (MeSH)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Inbred ICR (MeSH)</term><term>Myocardium (enzymology)</term><term>Nervous System (embryology)</term><term>Nervous System (enzymology)</term><term>Organ Specificity (MeSH)</term><term>Oxidoreductases (MeSH)</term><term>Pregnancy (MeSH)</term><term>Proteins (analysis)</term><term>Proteins (metabolism)</term><term>Thioredoxins (analysis)</term><term>Thioredoxins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antioxydants (MeSH)</term><term>Développement embryonnaire et foetal (MeSH)</term><term>Embryon de mammifère (enzymologie)</term><term>Femelle (MeSH)</term><term>Glutarédoxines (MeSH)</term><term>Grossesse (MeSH)</term><term>Immunohistochimie (MeSH)</term><term>Myocarde (enzymologie)</term><term>Mâle (MeSH)</term><term>Oxidoreductases (MeSH)</term><term>Protéines (analyse)</term><term>Protéines (métabolisme)</term><term>Souris (MeSH)</term><term>Souris de lignée ICR (MeSH)</term><term>Spécificité d'organe (MeSH)</term><term>Système nerveux (embryologie)</term><term>Système nerveux (enzymologie)</term><term>Thiorédoxines (analyse)</term><term>Thiorédoxines (métabolisme)</term><term>Âge gestationnel (MeSH)</term><term>Épithélium (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proteins</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antioxidants</term><term>Glutaredoxins</term><term>Oxidoreductases</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines</term><term>Thiorédoxines</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Système nerveux</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Nervous System</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Embryon de mammifère</term><term>Myocarde</term><term>Système nerveux</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Embryo, Mammalian</term><term>Epithelium</term><term>Myocardium</term><term>Nervous System</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines</term><term>Thiorédoxines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Embryonic and Fetal Development</term><term>Female</term><term>Gestational Age</term><term>Immunohistochemistry</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term><term>Organ Specificity</term><term>Pregnancy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antioxydants</term><term>Développement embryonnaire et foetal</term><term>Femelle</term><term>Glutarédoxines</term><term>Grossesse</term><term>Immunohistochimie</term><term>Mâle</term><term>Oxidoreductases</term><term>Souris</term><term>Souris de lignée ICR</term><term>Spécificité d'organe</term><term>Âge gestationnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ontogenesis of two anti-oxidative enzymes, thioredoxin (TRX) and glutaredoxin (GRX), was examined immunohistochemically in mouse embryos and fetuses at various developmental stages. They were found to be localized in various tissues, with some tissue specificity and temporal sequence. Both TRX and GRX began to be expressed in many tissues at embryonic (E) day E10 or E11 and tended to increase as the developmental stage advanced. In the heart and neuroepithelium, however, their immunoreactivity was already positive at E8.5. In some fetal organs like the liver, pancreas and kidney, TRX and GRX showed heterogeneous localization, suggesting that their expression may reflect the variable functional states of the cell. 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They were found to be localized in various tissues, with some tissue specificity and temporal sequence. Both TRX and GRX began to be expressed in many tissues at embryonic (E) day E10 or E11 and tended to increase as the developmental stage advanced. In the heart and neuroepithelium, however, their immunoreactivity was already positive at E8.5. In some fetal organs like the liver, pancreas and kidney, TRX and GRX showed heterogeneous localization, suggesting that their expression may reflect the variable functional states of the cell. 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Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Ital J Anat Embryol</MedlineTA><NlmUniqueID>9612303</NlmUniqueID><ISSNLinking>1122-6714</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>52500-60-4</RegistryNumber><NameOfSubstance UI="D013879">Thioredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" 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PubStatus="entrez"><Year>2001</Year><Month>12</Month><Day>6</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11732570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><noCountry><name sortKey="Nakamura, H" sort="Nakamura, H" uniqKey="Nakamura H" first="H" last="Nakamura">H. Nakamura</name><name sortKey="Shiota, K" sort="Shiota, K" uniqKey="Shiota K" first="K" last="Shiota">K. Shiota</name><name sortKey="Yodoi, J" sort="Yodoi, J" uniqKey="Yodoi J" first="J" last="Yodoi">J. Yodoi</name></noCountry><country name="Japon"><region name="Région du Kansai"><name sortKey="Kobayashi, M" sort="Kobayashi, M" uniqKey="Kobayashi M" first="M" last="Kobayashi">M. Kobayashi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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